SimBiology Model Analyzer

Analyze QSP, PK/PD, and mechanistic systems biology models

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Description

TheSimBiology Model Analyzerapp lets you analyze models of dynamic systems such as metabolic networks, signaling pathways, quantitative systems pharmacology (QSP) models, and pharmacokinetic/pharmacodynamic (PK/PD) models of drugs. It provides several methods to analyze models and various plots to visualize the results.

Using the app, you can:

Simulate a model to see its dynamic behavior over time.
Explore biological variability by simulating alternate scenarios such as virtual patients.
Estimate model parameters using nonlinear regression and nonlinear mixed-effects methods.
Perform parameter scans and sensitivity analysis to investigate the influence of model parameters and initial conditions on model behavior.
Specify units and let the app automatically convert the matching physical quantities to one consistent unit system.
Explore various dosing regimens.
Perform noncompartmental analysis (NCA) to compute PK parameters of a drug from its PK data.
View analysis results in various plots.

Available Plots

The app lets you visualize the analysis results using various plots, including:

Time course of model quantities
Sensitivity matrix
Overlay of estimated results on experimental data
Plots to measure fit quality, such as confidence interval plots, residuals plots, residual distribution plots, actual-versus-predicted plots, and box plots
Scatter plot matrix
Percentile plot

Open the SimBiology Model Analyzer App

MATLAB^®toolstrip: On theAppstab, underComputational Biology, click the app icon.
MATLAB command prompt: EntersimBiologyModelAnalyzer.

Examples

Programmatic Use

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`simBiologyModelAnalyzer`

simBiologyModelAnalyzeropens theSimBiology Model Analyzer应用程序。

`simBiologyModelAnalyzer(m1)`

simBiologyModelAnalyzer(m1)opens the SimBiology modelm1in theSimBiology Model Analyzer应用程序。If you also have theSimBiology Model Builderapp open at the same time, both apps share the same model.

If theSimBiology Model BuilderorSimBiology Model Analyzerapp is already open, you cannot load a model or project from the command line. Load the model from the app directly.

`simBiologyModelAnalyzer(prjFile)`

simBiologyModelAnalyzer(prjFile)opens the project fileprjFilein theSimBiology Model Analyzer应用程序。fileis a string or character vector specifying a file name or path and file name of a SimBiology project SBPROJ file. If you specify only a file name, the file must be on the MATLAB search path or in the current folder. If you also have theSimBiology Model Builderapp open at the same time, both apps share the same project.

If theSimBiology Model BuilderorSimBiology Model Analyzerapp is already open, you cannot load a model or project from the command line. Load the model from the app directly.

版本历史

Introduced in R2019b

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R2020b: Load a project or model from the command line when the app is open

Behavior changed in R2020b

If theSimBiology Model BuilderorSimBiology Model Analyzerapp is open, you cannot load a project or model from the command line using thesimBiologyModelBuilderorsimBiologyModelAnalyzerfunctions. Load the project or model from the app directly.